Copyright C 2001 Charlotte Kaufman. Reprinted with permission. 

Edited by Andrew W. Saul

(Dr. Kaufman kept meticulous patient records which support megavitamin therapy with niacinamide.  This 42-page chapter of statistical analysis contains 53 charts, tables, and graphs, which are not reproduced here. They are to be seen in the original book, available through this website. Ordering information is found at the bottom of this webpage.) 

Analysis of Certain Clinical Data for the Untreated and Treated Population

In this section, it will be seen from analysis of the Joint Range Indices of the untreated population that joint dysfunction in various clinical grades of severity is of common occurrence, and tends to increase in severity with increasing age. The grouped data show that, in general, the more severe the clinical grade of joint dysfunction, the more likely the patient is to have certain articular symptoms and signs, and the higher his Sedimentation Rate Index is likely to be. In general, untreated females are more likely to have certain articular symptoms and signs, and are more likely to have higher sedimentation rate indices than untreated males. It will further be demonstrated by an analysis of the grouped data that with niacinamide therapy (alone or in combination with other vitamins), there is a rise in the Joint Range Indices of the treated population. In general, the longer the duration of niacinamide treatment, the higher is the rise in the Joint Range Indices of the treated population.

The grouped data are arranged in the following manner:

Series 1. The presentation and analysis of certain data pertaining to the untreated population.

The population groups of Series 2,3 and 4 are composed of selected sub-groupings of the total untreated population who accepted niacinamide therapy for various periods of time, whether or not they adhered strictly to the prescribed dosage schedule of niacinamide (alone or in combination with other vitamins).

Series 2. The presentation and analysis of the Joint Range Indices of 266 male and female patients before niacinamide therapy, and after less than two months of niacinamide therapy.

Series 3. The presentation and analysis of the Joint Range Indices of maxi-mal Joint Range Indices after various periods of therapy (compiled Sep-tember 1, 1947). This series includes the Joint Range Indices of all patients who returned for one or more re-examinations.

Series 4. The analysis of the Joint Range Indices of 367 male and female patients before niacinamide therapy and their maximal Joint Range In-dices after various periods of niacinamide therapy (compiled September 1, 1948). This series includes the Joint Range Indices of all patients who re-turned for one or more re-examinations.

(End of introductory comments [p 146-7] for Chapter 4. Annotated charts, tables, and graphs constitute the next 40 pages [p 148-188] of The Common Form of Joint Dysfunction.